Annotation of CYP2B6*1, CYP2B6*18

CYP2B6 *18 is associated with increased concentrations of efavirenz in people with HIV as compared to CYP2B6 *1/*1.

From Publication

CYP2B6*6 and CYP2B6*18 Predict Long-Term Efavirenz Exposure Measured in Hair Samples in HIV-Positive South African Women. AIDS research and human retroviruses. 2016. Röhrich Carola R et al.
PMID:26655325(opens in new window) PMCID:PMC4892230(opens in new window) DOI:10.1089/AID.2015.0048(opens in new window)

Gene

CYP2B6

Haplotype

CYP2B6*1, CYP2B6*18

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1448994001

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    134

    Association p-value

    = 0.0045

    Biogeographical group
    More info on groups

    Multiple groups

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    Loading...