Annotation of rs3745274

Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.

"The median efavirenz plasma concentration (MEPC) was 2.2 mg/L [interquartile range (IQR) 1.7-2.8 mg/L] and was significantly higher in patients with the deficient CYP2B6 516T."

Gene

CYP2B6

Variant

rs3745274

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1448633511

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, clinical trial

    Study size

    191

    Association p-value

    < 0.0001

    Biogeographical group
    More info on groups

    Multiple groups

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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