Annotation of rs4570625

Allele G is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele T.

Response assessed as remission, defined as MADRS score =<10 at the end of treatment.

From Publication

Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. 2017. Marshe Victoria S et al.
PMID:28068779(opens in new window) DOI:10.1176/appi.ajp.2016.16050617(opens in new window)

Gene

TPH2

Variant

rs4570625

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1448601904

Score
More info on scoring

-2.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, retrospective

    Study size

    350

    Association p-value

    = 0.009

    Statistical analysis

    OR: 1.31

    Confidence interval

    0.88 - 1.94

    Biogeographical group
    More info on groups

    Multiple groups, 88.9% European, 9.4% African American, 1.4% Asian, 0.3% admixed

    Population description

    men; women

    Disease: Major depressive disorder

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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