Annotation of rs3745274

Allele T is associated with increased concentrations of efavirenz in people with HIV Infections as compared to allele G.

Significant association was seen at T=12 and 18 hours.

Gene

CYP2B6

Variant

rs3745274

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1448265859

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    Study size

    30

    Association p-value

    = 0.02

    Biogeographical group
    More info on groups

    Multiple groups, 22 white, 8 black

    Population description

    elderly; men; women

    Age Group: over age 50

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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