Annotation of rs3745274
Allele T is associated with increased concentrations of efavirenz in people with HIV Infections as compared to allele G.
Significant association was seen at T=12 and 18 hours.
From Publication
Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients. The Journal of antimicrobial chemotherapy. 2017. Sandkovsky Uriel et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Biogeographical group More info on groups
Population description
elderly; men; women
Age Group: over age 50
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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