Annotation of rs1468594

Allele A is not associated with response to corticosteroids in people with Asthma as compared to allele C.

The drugs were fluticasone furoate (82% of patients) and fluticasone propionate (18%). Response was assessed as change in FEV1 from baseline over 8 weeks (or 12 for HZA106837). The cohort was the meta-analysis of a combination of 7 randomized, double-blind, placebo-controlled, parallel-group, multi center studies conducted in 26 countries. They included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837.

From Publication

No evidence of large genetic effects on steroid response in asthma patients. The Journal of allergy and clinical immunology. 2017. Mosteller Michael et al.
PMID:27523435(opens in new window) DOI:10.1016/j.jaci.2016.05.032(opens in new window)

Gene

GLCCI1

Variant

rs1468594

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1448257965

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    clinical trial, meta-analysis, prospective

    Study size

    2672

    Association p-value

    = 0.155

    Population description

    children (pediatrics); men; women

    Study Cohort: The cohorts included FFA109684, FFA109685, FFA109687, FFA112059, HZA106827, HZA106829, and HZA106837.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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