Annotation of CYP2B6*1, CYP2B6*6

CYP2B6 *6 is associated with decreased metabolism of bupropion in women with Pregnancy as compared to CYP2B6 *1.

From Publication

Gene

CYP2B6

Haplotype

CYP2B6*1, CYP2B6*6

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1448257502

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, prospective

    Study size

    29

    Association p-value

    = 0.086

    Biogeographical group
    More info on groups

    Multiple groups, White and hispanic (36%), white and non-hispanic (57%)

    Population description

    women

    Drug: Bupropion and Pregnant

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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