Annotation of CYP2B6*1, CYP2B6*6
CYP2B6 *6 is associated with decreased metabolism of bupropion in women with Pregnancy as compared to CYP2B6 *1.
From Publication
Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy. Drug metabolism and disposition: the biological fate of chemicals. 2016. Fokina Valentina M et al.
Gene
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Biogeographical group More info on groups
Population description
women
Drug: Bupropion and Pregnant
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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