Annotation of rs3814055

Allele T is associated with decreased response to pazopanib in people with Carcinoma, Renal Cell as compared to allele C.

From Publication

Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011. Xu Chun-Fang et al.
PMID:21576632(opens in new window) DOI:10.1200/JCO.2010.32.9110(opens in new window)

Gene

NR1I2

Variant

rs3814055

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1448106937

Score
More info on scoring

2.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    clinical trial

    Study size

    379

    Association p-value

    = 0.03

    Allele frequency

    C=0.612

    Biogeographical group
    More info on groups

    Multiple groups, 84% white

    Population description

    men; women

    Study Cohort: Patients from VEG102616, VEG105192 and VEG107769. Partial responders plus complete responders.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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