Annotation of rs7412

Genotypes CT + TT are associated with increased response to rosuvastatin as compared to genotype CC.

The minor allele of this SNP is associated with increased fractional LDL-C reduction on rosuvastatin.

From Publication

Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circulation. Cardiovascular genetics. 2012. Chasman Daniel I et al.
PMID:22331829(opens in new window) DOI:10.1161/CIRCGENETICS.111.961144(opens in new window)

Gene

APOE

Variant

rs7412

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1447951982

Score
More info on scoring

0

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    clinical trial, GWAS

    Study size

    6989

    Association p-value

    = 5.8e-19

    Allele frequency

    T=0.15

    Biogeographical group
    More info on groups

    European

    Population description

    Study Cohort: genome-wide association study of LDL-C response was performed among a total of 6989 men and women of European ancestry who were randomly allocated to either rosuvastatin 20 mg daily or placebo

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    Loading...