Annotation of rs2231142

Genotype GG are not associated with concentrations of gefitinib in people with Carcinoma, Non-Small-Cell Lung as compared to genotypes GT + TT.

No significant difference in median area under the concentration-time curve from 0 to 24 hours (AUC0-24; p=0.323) or trough plasma concentration (C0; p=0.429) was seen between the two genotype groups. Please note that alleles have been complemented to the plus chromosomal strand.

Gene

ABCG2

Variant

rs2231142

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1447948394

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    31

    Association p-value

    > 0.05

    Biogeographical group
    More info on groups

    East Asian

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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