Annotation of rs35303484

Genotype AA is not associated with concentrations of efavirenz in people with HIV Infections as compared to genotypes AG + GG.

From Publication

An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients. Frontiers in genetics. 2015. Swart Marelize et al.
PMID:26779253(opens in new window) PMCID:PMC4703773(opens in new window) DOI:10.3389/fgene.2015.00356(opens in new window)

Gene

CYP2B6

Variant

rs35303484

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1447680733

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    222

    Association p-value

    = 0.7802

    Allele frequency

    A=0.903

    Biogeographical group
    More info on groups

    Sub-Saharan African

    Population description

    men; women

    Disease: HIV/AIDs patients, were receiving EFV-based treatment for at least 6 months.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    Loading...