Annotation of rs1127354
Genotype CC is not associated with response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotypes AA + AC.
The authors actually compared platelet counts between patients with normal or deficient ITPase activity. Patients with the composite genotypes of rs1127354 CC and rs7270101 AA had "normal ITPase activity" and all other genotype combinations were classified as "deficient". Univariable logistic regression normal ITPase activity was not significantly associated with virological relapse.
From Publication
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Statistical analysis
Confidence interval
Allele frequency
Biogeographical group More info on groups
Population description
Drug: pegintron and ribavirin; virologic response
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.