Annotation of rs2242046

Allele A is not associated with clearance of gemcitabine in people with Carcinoma, Non-Small-Cell Lung as compared to allele G.

Gene

SLC28A1

Variant

rs2242046

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1446900828

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, prospective

    Study size

    36

    Association p-value

    < 1.0E-5

    Allele frequency

    A=0.472

    Biogeographical group
    More info on groups

    Unknown. Netherlands

    Population description

    men; women

    Study Cohort: advanced NSCLC multicenter study in Netherlands

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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