Annotation of rs2108622

Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.

Average mean stable warfarin dose was 5.48+/-1.90 mg/day. Current age, age at operation, atrial fibrillation were all significantly associated with warfarin dose. Please note, alleles have been complimented to the + strand.

From Publication

Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves. European journal of clinical pharmacology. 2015. Chung Jee-Eun et al.
PMID:26257249(opens in new window) DOI:10.1007/s00228-015-1915-y(opens in new window)

Gene

CYP4F2

Variant

rs2108622

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1446765933

Score
More info on scoring

2.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    206

    Association p-value

    = 0.005

    Allele frequency

    C: case=0.11, control=0.89

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Study Cohort: EAST cohort; CC+CT=0, TT=1, parameter=0.881, r-squared =0.025

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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