Annotation of rs9934438

Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.

Average mean stable warfarin dose was 5.48+/-1.90 mg/day. Current age, age at operation, atrial fibrillation were all significantly associated with warfarin dose. Please note, alleles have been complimented to the + strand.

Gene

VKORC1

Variant

rs9934438

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1446765916

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    206

    Association p-value

    < 0.001

    Allele frequency

    A=0.11; G=0.89

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Study Cohort: EAST cohort; per A allele, parameter=-2.229, r-squared =0.286

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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