Annotation of rs846910

Genotype AA is associated with decreased dose-adjusted trough concentrations of tacrolimus in people with Kidney Transplantation as compared to genotypes AG + GG.

In patients who are CYP3A5 expressers (CYP3A5 *1/*1 or *1/*3). This variant is in strong linkage disequilibrium with rs846908 and rs4844880, and the AA-AA-AA haplotype for these three SNPs is also associated with decreased dose-adjusted trough concentrations of tacrolimus as compared to all other haplotypes (p=0.0367).

Gene

HSD11B1

Variant

rs846910

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1444935867

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    258

    Association p-value

    = 0.0367

    Allele frequency

    A=0.244

    Biogeographical group
    More info on groups

    East Asian

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    Loading...