Annotation of rs7438135

Genotypes AA + AG is associated with decreased concentrations of morphine in infants as compared to genotype GG.

In preterm newborns undergoing mechanical ventilation. Those who carried the A allele had lower morphine levels at 20 minutes post intubation, as compared to those with the GG genotype. A significant association was also seen when considering the morphine-3-glucuronide:morphine metabolic ratio (p=0.005).

Gene

UGT2B7

Variant

rs7438135

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1444934961

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    15

    Association p-value

    = 0.036

    Allele frequency

    G=0.29

    Population description

    infants

    Study Cohort: Morphine plasma concentrations

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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