Annotation of rs10465180

Genotype CC is associated with decreased response to clozapine in people with Schizophrenia as compared to genotypes CT + TT.

The association remained significant after permutation.

From Publication

Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes. Pharmacogenetics and genomics. 2015. Mitjans Marina et al.
PMID:25751398(opens in new window) DOI:10.1097/FPC.0000000000000132(opens in new window)

Gene

NTRK2

Variant

rs10465180

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1444699432

Score
More info on scoring

3.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    591

    Association p-value

    = 0.002

    Statistical analysis

    OR: 2.15

    Confidence interval

    1.3 - 3.55

    Biogeographical group
    More info on groups

    European

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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