Annotation of rs3745274

Genotypes GT + TT is associated with concentrations of efavirenz in people with HIV Infections as compared to genotype GG.

Multivariate analysis of factors influencing efavirenz concentrations over 32 weeks of antiretroviral treatment described CYP2B6*6 (516G>T, rs3745274), CYP2B6*11 (136A>G, rs35303484) and ABCB1 rs3842A>G genotypes were consistent significant predictors of plasma efavirenz concentration (see supplemental Table 1). The study also showed that long-term efavirenz auto-induction was more pronounced in patients with the CYP2B*1/*1 genotype compared to those carrying rs3745274 allele T and/or rs35303484 allele G. The study states that the CYP2B6*6, *11 and ABCB1 rs3842A>G genotypes were associated with higher efavirenz plasma concentrations.

Gene

CYP2B6

Variant

rs3745274

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1185234900

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    263

    Association p-value

    < 0.05

    Biogeographical group
    More info on groups

    Sub-Saharan African

    Population description

    men; women

    Study Cohort: Anti-retroviral-naive patients with (n=106) or without (n=157) concomitant TB co-infection were treated with efavirenz, zidovudine and lamivudine. Those also being treated for TB were on a rifampicin-based regimen (2 months of ethambutol, isoniazid and rifampicin followed by 4 months of isoniazid and rifampicin).

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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