Annotation of rs396991

Genotype CC is associated with increased response to trastuzumab in people with Breast Neoplasms as compared to genotypes AA + AC.

The response rate for 158 V/V and patients with either 158 V/F or 158 F/F genotype are 82%, 42% and 35%, respectively.

Gene

FCGR3A

Variant

rs396991

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1185003533

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    54

    Association p-value

    = 0.03

    Population description

    women

    Study Cohort: Fifty-four consecutive patients with HER-2/neu-amplified breast cancer receiving trastuzumab plus taxane for metastatic disease

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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