Annotation of rs61742245

Genotypes AA + AC is associated with increased dose of acenocoumarol as compared to genotype CC.

22 mg/week carriers vs 14 mg/week non-carriers.

Gene

VKORC1

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1185002340

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    3949

    Association p-value

    = 0.004

    Allele frequency

    A=0.004

    Biogeographical group
    More info on groups

    European

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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