Annotation of rs61742245
Genotypes AA + AC is associated with increased dose of acenocoumarol as compared to genotype CC.
22 mg/week carriers vs 14 mg/week non-carriers.
From Publication
Novel associations of VKORC1 variants with higher acenocoumarol requirements. PloS one. 2013. Anton Ana Isabel et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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