Annotation of rs1554203

Allele A is not associated with response to platinum in people with Lung Neoplasms as compared to allele G.

26 SNPs were selected which satisfied the following criteria: 1) SNPs were from HapMap Project Phase II of the Han Chinese population 2) were haplotype tagger SNPs 3) SNP minor allele frequency was higher than 5% in Han Chinese 4) the pairwise linkage disequilibrium correlation coefficient (r-squared) was greater than 0.8. After Bonferroni corrections no SNPs remained significantly associated with platinum drug efficacy.

From Publication

The association of transporter genes polymorphisms and lung cancer chemotherapy response. PloS one. 2014. Wang Ying et al.
PMID:24643204(opens in new window) PMCID:PMC3958404(opens in new window) DOI:10.1371/journal.pone.0091967(opens in new window)

Gene

AQP9

Variant

rs1554203

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1184756073

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Association p-value

    > 0.0006

    Allele frequency

    G=0.16; A=0.84

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Drug: patients with small-cell and non-small cell lung cancer receiving first line platinum chemotherapy (cisplatin and carboplatin). With Bonferroni correction the significance threshold reached 0.0006. No SNPs remained significantly associated with response to chemotherapy at this level of significance.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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