Annotation of rs11045879

Genotypes CC + CT is associated with increased concentrations of methotrexate in people with Osteosarcoma as compared to genotype TT.

Carriers of at least one polymorphic allele had significantly higher methotrexate levels after 24 h (median of 2.25 micromol/l compared with 1.70 micromol/l for carriers of two wild-type alleles, P =0.017) as well as methotrexate AUC (median of 31.9 micromol h/l compared with 26.8 micromol h/l for carriers of two wild-type alleles, P =0.011).

Gene

SLCO1B1

Variant

rs11045879

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1184747694

Score
More info on scoring

1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs11045879 (SLCO1B1); methotrexate; Neoplasms (level 3 Metabolism/PK)

Study Parameters

Study type

cohort

Study size

40

Association p-value

= 0.017

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.