Annotation of rs11045879
Genotypes CC + CT is associated with increased concentrations of methotrexate in people with Osteosarcoma as compared to genotype TT.
Carriers of at least one polymorphic allele had significantly higher methotrexate levels after 24 h (median of 2.25 micromol/l compared with 1.70 micromol/l for carriers of two wild-type alleles, P =0.017) as well as methotrexate AUC (median of 31.9 micromol h/l compared with 26.8 micromol h/l for carriers of two wild-type alleles, P =0.011).
From Publication
Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma. Pharmacogenetics and genomics. 2014. Goričar Katja et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.