Annotation of rs57098334

Genotype (CCCACCCGA)12/(CCCACCCGA)12 is associated with increased response to fluoxetine or sertraline in people with Depressive Disorder, Major.

Patients carrying the 12/12 VNTRs were compared to 9 and 10 VNTRs.

From Publication

Monoamine transporter gene polymorphisms and antidepressant response in koreans with late-life depression. JAMA. 2006. Kim Hyeran et al.
PMID:17018806(opens in new window) DOI:10.1001/jama.296.13.1609(opens in new window)

Gene

SLC6A4

Variant

rs57098334

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1184513240

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    136

    Association p-value

    = 0.01

    Biogeographical group
    More info on groups

    East Asian

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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