Annotation of rs7856096

Allele G is associated with decreased dose of warfarin as compared to allele A.

In the combined cohort each minor allele of rs7856096 contributed to -5.81 mg/week change in predicted dose (p= 3.93E-5) using the IWPC algorithm.

From Publication

Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans. Blood. 2014. Daneshjou Roxana et al.
PMID:25079360(opens in new window) PMCID:PMC4183989(opens in new window) DOI:10.1182/blood-2014-04-568436(opens in new window)

Gene

FPGS

Variant

rs7856096

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1184512426

Score
More info on scoring

2.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    475

    Association p-value

    = 3.93E-5

    Biogeographical group
    More info on groups

    African American/Afro-Caribbean

    Population description

    Study Cohort: Discovery cohort

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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