Annotation of rs9923231

Allele T is associated with decreased dose of warfarin in children as compared to allele C.

with an approximate decrease of daily dose of 0.66mg.

Gene

VKORC1

Variant

rs9923231

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1184473580

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    97

    Association p-value

    = 0.02

    Biogeographical group
    More info on groups

    European

    Population description

    children (pediatrics)

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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