Annotation of rs2412459

Genotype CT is associated with increased response to olanzapine, quetiapine, risperidone or ziprasidone in people with Schizophrenia as compared to genotype TT.

results did not reach significance.

From Publication

Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment. Pharmacogenetics and genomics. 2014. Drago Antonio et al.
PMID:24751813(opens in new window) DOI:10.1097/FPC.0000000000000052(opens in new window)

Gene

EIF2AK4

Variant

rs2412459

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1184469093

Score
More info on scoring

0

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs2412459 (EIF2AK4); olanzapine, quetiapine, risperidone or ziprasidone; Schizophrenia (level 3 Efficacy)

Study Parameters

Study type

cohort

Study size

1406

Association p-value

> 0.05

Population description

Study Cohort: replication cohort

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.