Annotation of rs763110

Genotypes CC + CT is not associated with response to Platinum compounds in people with Carcinoma, Non-Small-Cell Lung as compared to genotype TT.

No significant difference in response rates were seen between the genotype groups. Response was defined as experiencing complete or partial remission; non-response was stable or progressive disease.

From Publication

Multi-loci analysis reveals the importance of genetic variations in sensitivity of platinum-based chemotherapy in non-small-cell lung cancer. Molecular carcinogenesis. 2013. Liu Li et al.
PMID:22821704(opens in new window) DOI:10.1002/mc.21942(opens in new window)

Gene

FASLG

Variant

rs763110

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1184137499

Score
More info on scoring

-1.5

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

200

Association p-value

> 0.05

Statistical analysis

OR: 1.02

Confidence interval

0.28 - 3.68

Population description

Drug: Cisplatin + vinorelbine; carboplatin + vinorelbine; carboplatin + paclitaxel; cisplatin + paclitaxel/docetaxel.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.