Annotation of rs2231142

Allele G is not associated with clearance of tacrolimus in children with hemopoietic stem cell transplant as compared to allele T.

No significant difference in clearance or blood concentration of tacrolimus was seen between the genotypes of the rs2231142 SNP, at any point between 0 and 60 days after transplant. Please note alleles have been complemented to the plus chromosomal strand.

From Publication

Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT. Bone marrow transplantation. 2011. Yanagisawa R et al.
PMID:20383212(opens in new window) DOI:10.1038/bmt.2010.64(opens in new window)

Gene

ABCG2

Variant

rs2231142

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1183960210

Score
More info on scoring

-0.25

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

27

Population description

children (pediatrics)

Age Group: 1 - 13 years old.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.