Annotation of rs1799853
Allele T is associated with decreased metabolism of warfarin as compared to allele C.
Impaired metabolism was found for S-warfarin. T= CYP2C9*2; C= CYP2C9*1.
From Publication
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. Pharmacogenetics. 1994. Rettie A E et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Population description
Study Cohort: enzymes were expressed in HepG cells
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.