Annotation of rs2108622

Allele C is associated with decreased dose of warfarin in people with venous thromboembolism as compared to allele T.

The study purpose was to develop a model for stable maintenance warfarin dose prediction. Most patients had a history of venous thromboembolism. CC patients required a slightly lower dose than CT patients, who required a lower dose than TT patients.

Gene

CYP4F2

Variant

rs2108622

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1183701528

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    246

    Association p-value

    < 0.0002

    Allele frequency

    T=0.3

    Biogeographical group
    More info on groups

    Multiple groups, 94% were White (all were patients at Ottawa Hospital Thrombosis Clinic).

    Population description

    Disease: patients at Ottawa Hospital Thrombosis Clinic

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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