Annotation of rs2108622
Allele C is associated with decreased dose of warfarin in people with venous thromboembolism as compared to allele T.
The study purpose was to develop a model for stable maintenance warfarin dose prediction. Most patients had a history of venous thromboembolism. CC patients required a slightly lower dose than CT patients, who required a lower dose than TT patients.
From Publication
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Population description
Disease: patients at Ottawa Hospital Thrombosis Clinic
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
Loading...