Annotation of rs2359612

Allele A is associated with dose of warfarin.

This SNP explained 30% (P = 9.82 x 10(-100)) of the variation in warfarin dose. The direction of the allele:dose relationship is not stated.

From Publication

The largest prospective warfarin-treated cohort supports genetic forecasting. Blood. 2009. Wadelius Mia et al.
PMID:18574025(opens in new window) PMCID:PMC2630264(opens in new window) DOI:10.1182/blood-2008-04-149070(opens in new window)

Gene

VKORC1

Variant

rs2359612

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1183701268

Score
More info on scoring

2.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, prospective

    Study size

    1292

    Association p-value

    < 0.05

    Allele frequency

    A=0.39

    Biogeographical group
    More info on groups

    European

    Population description

    Drug: patients starting warfarin; from WARG study

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    Loading...