Annotation of rs6877011
Genotypes CG + GG are not associated with response to cisplatin, fluorouracil and oxaliplatin in people with Stomach Neoplasms as compared to genotype CC.
No significant association was found in progression free survival or overall survival.
From Publication
Tumor angiogenesis genotyping and efficacy of first-line chemotherapy in metastatic gastric cancer patients. Pharmacogenomics. 2013. Scartozzi Mario et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has not been used as evidence for any clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Population description
Study Cohort: Patients with HER-2 negative metastic gastric cancer recieving platinum-based chemotherapy (fluorouracil+cisplatin or fluorouracil+oxaliplatin).
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.