Annotation of rs3957357

Genotype AA is associated with increased clearance of busulfan in children with Transplantation as compared to genotypes AG + GG.

From Publication

Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation. Pharmacogenomics. 2013. ten Brink Marloes H et al.
PMID:24192117(opens in new window) DOI:10.2217/pgs.13.159(opens in new window)

Gene

GSTA1

Variant

rs3957357

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1183690897

Score
More info on scoring

1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, retrospective

    Study size

    81

    Association p-value

    = 0.004

    Population description

    Study Cohort: Children 18 years or younger receiving busulfan conditioning prior to hematopoietic stem cell transplantation.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.