Annotation of rs2071559

Allele A is not associated with response to ranibizumab in people with Macular Degeneration as compared to allele G.

Age-related macular degeneration. No significant differences in best-corrected visual acuity (BCVA) changes or central subfield macular thickness (CSMT) changes were seen between baseline and 3 or 6 months of treatment between any of the genotypes.

Gene

KDR

Variant

rs2071559

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1183682059

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    102

    Association p-value

    = 0.182

    Biogeographical group
    More info on groups

    East Asian

    Population description

    elderly

    Age Group: 60 years or older. p-value refers to change in CSMT between baseline and 3 months of treatment.

    2.

    Study type

    cohort

    Study size

    102

    Association p-value

    = 0.618

    Biogeographical group
    More info on groups

    East Asian

    Population description

    elderly

    Age Group: 60 years or older. p-value refers to change in BCVA between baseline and 3 months of treatment.

    3.

    Study type

    cohort

    Study size

    102

    Association p-value

    = 0.662

    Biogeographical group
    More info on groups

    East Asian

    Population description

    elderly

    Age Group: 60 years or older. p-value refers to change in BCVA between baseline and 6 months of treatment.

    4.

    Study type

    cohort

    Study size

    102

    Association p-value

    = 0.692

    Biogeographical group
    More info on groups

    East Asian

    Population description

    elderly

    Age Group: 60 years or older. p-value refers to change in CSMT between baseline and 6 months of treatment.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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