Annotation of rs1799964

Genotypes CC + CT are not associated with response to lansoprazole, omeprazole or rabeprazole in people with Helicobacter Infections as compared to genotype TT.

No significant difference in the percentage of patients who failed Helicobacter pylori (H. pylori) treatment were seen between the two genotype groups. Patients were also given amoxicillin and clarithromycin, and were treated for 1 week.

From Publication

Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy. Clinical pharmacology and therapeutics. 2006. Sugimoto Mitsushige et al.
PMID:16815316(opens in new window) DOI:10.1016/j.clpt.2006.03.007(opens in new window)

Gene

TNF

Variant

rs1799964

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1183680064

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    349

    Association p-value

    = 0.6888

    Statistical analysis

    OR: 1.222

    Confidence interval

    0.666 - 2.442

    Allele frequency

    T=0.85

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Disease: Gastric ulcer, duodenal ulcer or gastritis. Drugs were omeprazole (n=90), lansoprazole (n=214) and rabeprazole (n=56).

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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