Annotation of rs4762

Genotype GG is not associated with response to atenolol or irbesartan in people with Hypertension as compared to genotype AG.

No significant differences in the change in diastolic or systolic blood pressure after 3 months of treatment were seen between the genotypes. 43 patients were given atenolol and 43 were given irbesartan; these two drug cohorts were analyzed as separate groups.

Gene

AGT

Variant

rs4762

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1183615160

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    86

    Allele frequency

    G=0.16

    Biogeographical group
    More info on groups

    European

    Population description

    Study Cohort: SILVHIA trial. Patients with hypertension and left ventricular hypertrophy. No p-value given only non-significance stated.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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