Annotation of rs3184504

Allele T is not associated with response to hydrochlorothiazide in people with Hypertension as compared to allele C.

Not significant when using Bonferroni-corrected alpha of 0.0014. Response was assessed by change in diastolic blood pressure (DBP) after 9 weeks of treatment.

From Publication

Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study. Circulation. Cardiovascular genetics. 2012. Gong Yan et al.
PMID:23087401(opens in new window) PMCID:PMC3529147(opens in new window) DOI:10.1161/CIRCGENETICS.112.964080(opens in new window)

Gene

SH2B3

Variant

rs3184504

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1183491528

Score
More info on scoring

-2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    148

    Association p-value

    = 0.047

    Biogeographical group
    More info on groups

    African American/Afro-Caribbean

    Population description

    Study Cohort: Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR). p-value for association with change in DBP, adjusted for baseline blood pressure and other variables.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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