Annotation of rs5186

Genotype AA is associated with increased response to losartan in people with Liver Cirrhosis as compared to genotypes AC + CC.

Cirrhotiç patients with portal hypertension and the AA genotype showed a higher decrease of hepatic venous pressure gradient as compared to patients carrying the C allele.

From Publication

A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. The American journal of gastroenterology. 2005. Sookoian Silvia et al.
PMID:15743363(opens in new window) DOI:10.1111/j.1572-0241.2005.41168.x(opens in new window)

Gene

AGTR1

Variant

rs5186

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1144135755

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs5186 (AGTR1); losartan; Liver Cirrhosis (level 3 Efficacy)

Study Parameters

Study type

cohort

Study size

23

Association p-value

< 0.01

Population description

Disease: Cirrhosis with portal hypertension

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.