Annotation of rs5186
Genotype AA is associated with increased response to losartan in people with Liver Cirrhosis as compared to genotypes AC + CC.
Cirrhotiç patients with portal hypertension and the AA genotype showed a higher decrease of hepatic venous pressure gradient as compared to patients carrying the C allele.
From Publication
A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. The American journal of gastroenterology. 2005. Sookoian Silvia et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Population description
Disease: Cirrhosis with portal hypertension
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.