ICPC - International Clopidogrel Pharmacogenomics Consortium
| Host Institution | PharmGKB |
| icpc@pharmgkb.org | |
| Drug(s) | Clopidogrel |
Abstract
The overall goal of the ICPC is to amass very large sample sizes and expertise from across the globe to dissect the genetic underpinnings of variable response to clopidogrel. There has been great excitement and also recent controversy regarding the role of CYP2C19 loss of function variants on clinical outcomes in clopidogrel-treated patients. The ICPC seeks to further increase sample size through de novo genotyping as well as by performing additional analyses of platelet function and clinical outcomes to better understand the role of CYP2C19 polymorphism in clopidogrel response.
Our work and those of others strongly suggest that approximately 70-80% of the variation in clopidogrel response is heritable. Another major goal of the ICPC is to identify novel variants for clopidogrel response through candidate gene and genome-wide approaches.
Better understanding of how genetic variation affects clopidogrel response will greatly advance the field toward evidence-based translation into clinical practice.
As a member of the ICPC, you will be expected to contribute DNA and/or genotype information and relevant phenotype information that will be deposited into a central database for analysis. If DNA is limiting, the ICPC can offer whole genome amplification (WGA) free of charge. Some of the WGA DNA will be used by the ICPC and the remainder returned to the contributing group. Please let us know by return email to feedback (feedback@pharmgkb.org) of your interest in joining the ICPC. You may review the ICPC's Memorandum of Understanding as well as a questionnaire to begin to define the minimal dataset required for participation. Inclusiveness and transparency will be key to the success of the Consortium.
ICPC Team
Organizing Committee
- RIKEN, Japan and Institute of Biomedical Sciences, Academia Sinica, Taiwan
- Ming-Ta Michael Lee
- Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany
- Matthias Schwab
- Mount Sinai School of Medicine, USA
- Jean-Sebastien Hulot
- Penn State University, USA
- Marylyn Ritchie
- Stanford University - PharmGKB, USA
- Teri E. Klein
- Russ B. Altman
- University of Maryland, USA
- Alan Shuldiner
- Ruth Cosentino
- University Pierre et Marie CURIE, France
- Tabassome Simon
ICPC Membership
- Central South University, Institute of Clinical Pharmacology, China
- Hong-Hao Zhou
- Chang Gung Memorial Hospital, Taiwan
- Ming-Shien Wen
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany
- Stephan Winter
- Hamamatsu University School of Medicine, Japan
- Takahisa Furuta
- Inje University, South Korea
- Jae Gook Shin
- MinKyung Oh
- Institute of Biomedical Sciences, Academia Sinica, Taiwan, and RIKEN, Japan
- Ming Ta Michael Lee
- Medical University of Vienna, Austria
- Jolanta Siller-Matula
- National University Hospital, Denmark
- Lene Holmvang
- Quebec Heart and Lung Institute, Canada
- Jean-Pierre Déry
- Ugo Déry
- Sinai Center for Thrombosis Research, Sinai Hospital Baltimore, USA
- Paul A. Gurbel
- St Antonius Hospital Nieuwegein, Netherlands
- Jurrien ten Berg
- Thomas Bergmeijer
- University of Ferrara, Italy
- Marco Valgimigli
- University of Florence, Italy
- Gian Franco Gensini
- Betti Giusti
- Rossella Marcucci
- University of Geneva, Switzerland
- Pierre Fontana
- Jean-Luc Reny
- University Hospital Tuebingen, Germany
- Tobias Geisler
- Meinrad Gawas
- Mathias Schwab
- Elke Schaffeler
- Universitates-Herzzentrum Freiburg - Bad Krozingen, Germany
- Dietmar Trenk
- University of Maryland School of Medicine, USA
- Alan Shuldiner
- Adam Fisch
- Ankita Parihar
- Joshua Lewis
- Jeffrey O'Connell
- Sarah Stephens
- Richard Horenstein
- Amber Beitelshees
- Joshua Backman
- University of Patras, Greece
- Dimitrios Alexopoulos
- University of Pécs, Hungary
- Daniel Aradi
- Vall d’Hebron Institute of Research, Spain
- Israel Fernandez-Cadenas
- Joan Montaner
- Cristina Gallego
- Caty Carrera
- Jurek Krupinski
- Vanderbilt University School of Medicine, USA
- Dan Roden
- Christie Ingram
- Dana Crowford
- Hua Xu
- Jessica Delaney
- Joshua Denny
- Peter Weeke
- Matt Oetjens