Clinical Annotation for rs1801394 (FASTKD3, MTRR); sevoflurane (level 3)
Level of Evidence
Phenotype Category
Other
Genes
Variant
Drugs
PharmGKB ID
1452003640
| Allele | Phenotype |
|---|---|
| AA | Patients with the rs1801394 AA genotype who are treated with sevoflurane may have increased mean arterial pressure as compared to patients with the GG or AG genotypes. Other genetic and clinical factors may also influence mean arterial pressure. |
| AG | Patients with the rs1801394 AG genotype who are treated with sevoflurane may have decreased mean arterial pressure as compared to patients with the AA genotype. Other genetic and clinical factors may also influence mean arterial pressure. |
| GG | Patients with the rs1801394 GG genotype who are treated with sevoflurane may have decreased mean arterial pressure as compared to patients with the AA genotype. Other genetic and clinical factors may also influence mean arterial pressure. |
Level of Evidence Calculation More information
- Total Score
- 1
- Score Breakdown
- Variant Annotations = 1
- Dosing Guideline Annotations = 0
- Drug Label Annotations = 0
- Calculated Level from Score
- Level 3Learn more about Clinical Annotation Levels of Evidence(opens in new window)
Evidence
- 0 Dosing Guideline Annotations
- 0 Drug Label Annotations
- 1 Variant Annotation from 1 Publication
- 1 Positive association Variant Annotation
- 0 Negative association Variant Annotations
1. Annotation of rs1801394 in FASTKD3MTRR
Genotypes AG + GG are associated with decreased mean arterial pressure when exposed to sevoflurane in people with otorhinolaryngology surgery as compared to genotype AA.
The degree of sedation and hemodynamic effects in response to the anesthetic sevoflurane were studied in individuals undergoing otorhinolaryngology surgery.
From Publication
Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane. Journal of clinical pharmacology. 2023. Zhao Shuai et al.
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Study Parameters
Study type
Study size
Association p-value
Biogeographical group More info on groups
Country
Population description
men; women
Study Cohort: In the loss of response to trapezius squeeze (LOTS) state, minor allele (GA/GG) carriers showed significantly decreased mean arterial pressure (MAP) (i.e. an increased change in MAP).
History
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