Clinical Annotation for rs1801394 (FASTKD3, MTRR); sevoflurane (level 3)

Level of Evidence

Phenotype Category

Other

Genes

Variant

Drugs

PharmGKB ID

1452003640
AllelePhenotype
AAPatients with the rs1801394 AA genotype who are treated with sevoflurane may have increased mean arterial pressure as compared to patients with the GG or AG genotypes. Other genetic and clinical factors may also influence mean arterial pressure.
AGPatients with the rs1801394 AG genotype who are treated with sevoflurane may have decreased mean arterial pressure as compared to patients with the AA genotype. Other genetic and clinical factors may also influence mean arterial pressure.
GGPatients with the rs1801394 GG genotype who are treated with sevoflurane may have decreased mean arterial pressure as compared to patients with the AA genotype. Other genetic and clinical factors may also influence mean arterial pressure.

Level of Evidence Calculation More information

Total Score
1
Score Breakdown
  • Variant Annotations = 1
  • Dosing Guideline Annotations = 0
  • Drug Label Annotations = 0
Calculated Level from Score
Level 3Learn more about Clinical Annotation Levels of Evidence(opens in new window)

Evidence

  • 0 Dosing Guideline Annotations
  • 0 Drug Label Annotations
  • 1 Variant Annotation from 1 Publication
    • 1 Positive association Variant Annotation
    • 0 Negative association Variant Annotations

1. Annotation of rs1801394 in FASTKD3MTRR

Genotypes AG + GG are associated with decreased mean arterial pressure when exposed to sevoflurane in people with otorhinolaryngology surgery as compared to genotype AA.

The degree of sedation and hemodynamic effects in response to the anesthetic sevoflurane were studied in individuals undergoing otorhinolaryngology surgery.

Variant

rs1801394

Phenotype Category

Other

Association Significance

The study reports this association is significant

PharmGKB ID

1451980440

Study Parameters

Study type

cohort

Study size

151

Association p-value

= 0.017

Biogeographical group
More info on groups

East Asian

Country

China

Population description

men; women

Study Cohort: In the loss of response to trapezius squeeze (LOTS) state, minor allele (GA/GG) carriers showed significantly decreased mean arterial pressure (MAP) (i.e. an increased change in MAP).

History

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