Clinical Annotation for rs3786547 (CYP2B6); nevirapine; HIV Infections (level 3 Toxicity)

Level of Evidence

Phenotype Category

Toxicity

Genes

Variant

Drugs

Phenotypes

PharmGKB ID

1444673039
AllelePhenotype
CCPatients with the CC genotype and HIV may be at an increased risk for experiencing severe cutaneous adverse events when treated with nevirapine, as compared to patients with the TT genotype. Other genetic and clinical factors may also influence nevirapine-related adverse reactions.
CTPatients with the CT genotype and HIV may be at an increased risk for experiencing severe cutaneous adverse events when treated with nevirapine, as compared to patients with the TT genotype, or a decreased risk as compared to patients with the CC genotype. Other genetic and clinical factors may also influence nevirapine-related adverse reactions.
TTPatients with the TT genotype and HIV may be at a decreased risk for experiencing severe cutaneous adverse events when treated with nevirapine, as compared to patients with the CC genotype. Other genetic and clinical factors may also influence nevirapine-related adverse reactions.

Level of Evidence Calculation More information

Total Score
2.5
Score Breakdown
  • Variant Annotations = 2.5
  • Dosing Guideline Annotations = 0
  • Drug Label Annotations = 0
Level Modifiers
Calculated Level from Score
Level 3Learn more about Clinical Annotation Levels of Evidence(opens in new window)

Evidence

  • 0 Dosing Guideline Annotations
  • 0 Drug Label Annotations
  • 1 Variant Annotation from 1 Publication
    • 1 Positive association Variant Annotation
    • 0 Negative association Variant Annotations

1. Annotation of rs3786547 in CYP2B6

Allele C is associated with increased risk of Drug Toxicity when treated with nevirapine in people with HIV Infections.

The frequency of the C allele was greater in those with nevirapine-related cutaneous adverse events as compared to healthy controls. This SNP was in LD with rs2054674 (r2 = 0.982) and rs3745274 (r2 > 0.90). p-value corrected for multiple testing. This SNP was not associated with hepatic adverse events after correcting for multiple comparisons.

Gene

CYP2B6

Variant

rs3786547

Phenotype Category

Toxicity

Association Significance

The study reports this association is significant

PharmGKB ID

1185002114

Study Parameters

Study type

case/control

Study size

762 (cases=175; controls=587)

Association p-value

= 0.029

Statistical analysis

OR: 1.74

Confidence interval

1.34 - 2.25

Biogeographical group
More info on groups

Multiple groups, Asian, Black, White

Population description

Disease: Severe cutaneous toxicity - grade III or IV on NIAID Division of AIDS criteria.

History

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