Summary annotation for HLA-B*13:01; sulfasalazine; drug reaction with eosinophilia and systemic symptoms (level 3 Toxicity)
Level of Evidence
Phenotype Category
Toxicity
Genes
Haplotypes
Drugs
Phenotypes
ID
1296598640
| Allele | Phenotype |
|---|---|
| *13:01 Function not assigned More allele information | Patients with the HLA-B*13:01 allele may have an increased risk of DRESS when treated with sulfasalazine as compared to patients with no HLA-B*13:01 alleles or negative for the HLA-B*13:01 test. Other genetic and clinical factors may also influence a patient's risk of sulfasalazine-induced adverse reactions. |
Level of Evidence Calculation More information
- Total Score
- 3
- Score Breakdown
- Variant Annotations = 3
- Dosing Guideline Annotations = 0
- Drug Label Annotations = 0
- Level Modifiers
- Calculated Level from Score
- Level 3Learn more about Summary Annotation Levels of Evidence(opens in new window)
Evidence
- 0 Dosing Guideline Annotations
- 0 Drug Label Annotations
- 1 Variant Annotation from 1 Publication
- 1 Positive association Variant Annotation
- 0 Negative association Variant Annotations
1. Annotation of HLA-B haplotype HLA-B*13:01
HLA-B *13:01 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with sulfasalazine.
Allele described as *13:01 in the comparison with healthy controls, and *13:01:01 in the comparison with tolerant controls.
From Publication
HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population. Pharmacogenomics. 2014. Yang Fanping et al.
Gene
Haplotype
Phenotype Category
Association Significance
ID
Score More info on scoring
Study Parameters
1.
Study type
Study size
Association p-value
Statistical analysis
Confidence interval
Biogeographical group More info on groups
Population description
Study Cohort: Case= 6 patients with Salazosulfapyridine-induced DRESS, controls = salazosulfapyridine-tolerant patients. Allele carrier frequency was compared between these groups.
2.
Study type
Study size
Association p-value
Statistical analysis
Confidence interval
Biogeographical group More info on groups
Population description
Study Cohort: Cases = 6 patients with Salazosulfapyridine-induced DRESS, controls = healthy Han Chinese subjects. Allele carrier frequency was compared between these groups.
History
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