Annotation of rs1800532

Genotype GG is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to genotypes GT + TT.

From Publication

Pharmacogenetics in major depression: a comprehensive meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry. 2013. Niitsu Tomihisa et al.
PMID:23733030(opens in new window) DOI:10.1016/j.pnpbp.2013.05.011(opens in new window)

Gene

TPH1

Variant

rs1800532

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

ID

982028731

Score
More info on scoring

-1

Evidence for Summary Annotations

This annotation has been used as evidence for the following summary annotations.

  1. rs1800532 (TPH1); antidepressants, citalopram, escitalopram, fluoxetine or paroxetine; Depressive Disorder, Major (level 4 Efficacy)

Study Parameters

Study type

meta-analysis

Study size

2814

Association p-value

= 0.09

Statistical analysis

OR: 1.29

Confidence interval

0.96 - 1.75

Biogeographical group
More info on groups

Multiple groups

Note: Alleles in ClinPGx are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in ClinPGx annotations.

History

No history available.