Selected PGx Associations

The criteria for this list of Drug-Gene pairs is 1) each pair must be annotated in either a dosing guideline annotation or a drug label annotation and 2) each pair must be specified in more than 1 type of annotation (dosing guideline, drug label, clinical annotation, variant annotation, VIP, or pathway).

Drug Gene Types of data
abacavir HLA-B
acenocoumarol CYP2C9
DG No Drug Label available CA VA No VIP available No VIP available
acenocoumarol VKORC1
acetaminophen CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
afatinib EGFR
allopurinol HLA-B
amitriptyline CYP2C19
amitriptyline CYP2D6
anastrozole ESR1
No Dosing Guideline available DL CA VA No VIP available No VIP available
anastrozole ESR2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
anastrozole PGR
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
aripiprazole CYP2D6
aripiprazole CYP3A4
atazanavir UGT1A1
atomoxetine CYP2D6
atorvastatin CYP3A4
atorvastatin HMGCR
atorvastatin LDLR
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
atorvastatin SLCO1B1
axitinib CYP2C19
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
axitinib CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
axitinib CYP3A5
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
axitinib UGT1A1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
azathioprine TPMT
azathioprine XDH
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
belinostat UGT1A1
No Dosing Guideline available DL CA VA No VIP available No VIP available
boceprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
bosutinib ABL1
brivaracetam CYP2C19
No Dosing Guideline available DL CA VA No VIP available No VIP available
capecitabine DPYD
carbamazepine CYP3A4
carbamazepine HLA-A
carbamazepine HLA-B
carisoprodol CYP2C19
carvedilol CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
carvedilol CYP2D6
celecoxib CYP2C9
celecoxib CYP2D6
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
cetuximab EGFR
cetuximab KRAS
cetuximab NRAS
chloroquine G6PD
cisplatin TPMT
No Dosing Guideline available DL CA VA No VIP available No VIP available
citalopram CYP2C19
citalopram CYP2D6
citalopram CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
clobazam CYP2C19
No Dosing Guideline available DL CA VA No VIP available No VIP available
clomipramine CYP1A2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
clomipramine CYP2C19
clomipramine CYP2D6
clopidogrel CYP1A2
clopidogrel CYP2B6
clopidogrel CYP2C19
clopidogrel CYP2C9
clozapine CYP1A2
No Dosing Guideline available DL CA VA No VIP available No VIP available
clozapine CYP2D6
clozapine DRD2
No Dosing Guideline available DL CA VA No VIP available No VIP available
codeine CYP2D6
codeine CYP3A4
codeine UGT2B7
crizotinib ABCB1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
dabrafenib BRAF
dabrafenib NRAS
daclatasvir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
dapsone G6PD
dasatinib ABL1
daunorubicin SLC28A3
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
desflurane CACNA1S
No Dosing Guideline available DL CA No Variant Annotation available No VIP available No VIP available
desflurane RYR1
desipramine CYP2D6
dextromethorphan CYP2D6
dextromethorphan CYP3A4
diazepam CYP2C19
diazepam CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
diazepam CYP3A4
dolutegravir UGT1A1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
donepezil ABCB1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
donepezil CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
donepezil CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
doxepin CYP2C19
doxepin CYP2D6
doxorubicin SLC28A3
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
duloxetine CYP2D6
DG DL No Clinical Annotation available VA No VIP available No VIP available
efavirenz CYP1A2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
efavirenz CYP2B6
efavirenz CYP2C19
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
efavirenz CYP3A4
erlotinib CYP1A2
erlotinib CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
erlotinib EGFR
erlotinib UGT1A1
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
erythromycin ABCB1
escitalopram CYP1A2
No Dosing Guideline available DL CA VA No VIP available No VIP available
escitalopram CYP2C19
escitalopram CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
esomeprazole CYP2C19
everolimus CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
exemestane CYP3A4
No Dosing Guideline available DL CA VA No VIP available No VIP available
exemestane ESR1
No Dosing Guideline available DL CA VA No VIP available No VIP available
fentanyl CYP3A4
fesoterodine CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
flecainide CYP2D6
fluorouracil DPYD
fluoxetine CYP2D6
flurbiprofen CYP2C9
No Dosing Guideline available DL CA VA No VIP available No VIP available
flurbiprofen UGT2B7
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
fluvoxamine CYP1A2
fluvoxamine CYP2C19
fluvoxamine CYP2D6
galantamine CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
gefitinib CYP2D6
gefitinib CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
gefitinib EGFR
glibenclamide CYP2C9
glibenclamide G6PD
gliclazide CYP2C9
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
glimepiride CYP2C9
haloperidol CYP2D6
homoharringtonine ABL1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
hormonal contraceptives for systemic use F5
hydralazine NAT2
iloperidone CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
imatinib ABL1
imatinib CYP2D6
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
imatinib CYP3A4
imatinib KIT
imipramine CYP2C19
imipramine CYP2D6
indacaterol ADRB2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
indinavir CYP3A4
irinotecan CYP3A4
irinotecan UGT1A1
isoflurane CACNA1S
No Dosing Guideline available DL CA VA No VIP available No VIP available
isoflurane RYR1
isoniazid NAT2
ivacaftor CFTR
ivacaftor / lumacaftor CFTR
No Dosing Guideline available DL CA VA No VIP available No VIP available
lansoprazole CYP2C19
lapatinib ERBB2
lapatinib HLA-DQA1
No Dosing Guideline available DL CA VA No VIP available No VIP available
lapatinib HLA-DRB1
No Dosing Guideline available DL CA VA No VIP available No VIP available
letrozole CYP2A6
letrozole ESR1
No Dosing Guideline available DL CA VA No VIP available No VIP available
letrozole ESR2
No Dosing Guideline available DL CA VA No VIP available No VIP available
letrozole PGR
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
lidocaine CYP3A4
mafenide G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
mercaptopurine TPMT
methylene blue BLVRB
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
methylene blue G6PD
metoclopramide CYB5R3
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
metoprolol CYP2D6
mirtazapine CYP2D6
DG No Drug Label available CA VA No VIP available No VIP available
moclobemide CYP2C19
modafinil CYP2C19
nalidixic acid G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
nelfinavir CYP2C19
nelfinavir CYP3A
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
nelfinavir CYP3A4
nilotinib ABL1
nilotinib UGT1A1
No Dosing Guideline available DL CA VA No VIP available No VIP available
nitrofurantoin G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
nortriptyline CYP2D6
olanzapine CYP1A2
No Dosing Guideline available DL CA VA No VIP available No VIP available
olanzapine CYP2D6
olanzapine CYP3A
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
omeprazole CYP2C19
ondansetron CYP2D6
ondansetron CYP3A4
oxcarbazepine CYP2C19
oxcarbazepine HLA-B
oxycodone CYP2D6
DG No Drug Label available CA VA No VIP available No VIP available
panitumumab EGFR
panitumumab KRAS
pantoprazole CYP2C19
pantoprazole CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
paroxetine CYP2D6
pazopanib ABCG2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
pazopanib CYP2C8
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
pazopanib FLT4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
pazopanib HLA-B
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
pazopanib KDR
No Dosing Guideline available DL CA VA No VIP available No VIP available
pazopanib UGT1A1
No Dosing Guideline available DL CA VA No VIP available No VIP available
peginterferon alfa-2a IFNL3
DG No Drug Label available CA VA No VIP available No VIP available
peginterferon alfa-2b IFNL3
pegloticase G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
perphenazine CYP2D6
pertuzumab ERBB2
phenprocoumon CYP2C9
DG No Drug Label available CA VA No VIP available No VIP available
phenprocoumon VKORC1
DG No Drug Label available CA VA No VIP available No VIP available
phenytoin CYP2C19
phenytoin CYP2C9
phenytoin HLA-B
pimozide CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
pimozide CYP3A4
piroxicam CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
ponatinib ABL1
prasugrel CYP2B6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
prasugrel CYP2C19
No Dosing Guideline available DL CA VA No VIP available No VIP available
prasugrel CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
prasugrel CYP3A5
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
prasugrel P2RY12
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
pravastatin APOE
No Dosing Guideline available DL CA VA No VIP available No VIP available
pravastatin LDLR
No Dosing Guideline available DL CA VA No VIP available No VIP available
primaquine G6PD
probenecid G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
propafenone CYP2D6
propranolol CYP2C19
propranolol CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
pyrazinamide NAT2
No Dosing Guideline available DL CA VA No VIP available No VIP available
quinidine ABCB1
quinidine CYP3A4
quinine ABCB1
quinine CYP3A4
quinine G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
rabeprazole CYP2C19
rasburicase G6PD
ribavirin HLA-B
ribavirin IFNL3
DG No Drug Label available CA VA No VIP available No VIP available
rifampin NAT2
No Dosing Guideline available DL CA VA No VIP available No VIP available
risperidone CYP2D6
ritonavir CYP3A4
rosuvastatin ABCG2
No Dosing Guideline available DL CA VA No VIP available No VIP available
rosuvastatin CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
rosuvastatin SLCO1B1
sertraline CYP2C19
DG No Drug Label available CA VA No VIP available No VIP available
sevoflurane CACNA1S
No Dosing Guideline available DL CA No Variant Annotation available No VIP available No VIP available
sevoflurane RYR1
sildenafil CYP3A4
simeprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
simvastatin SLCO1B1
sirolimus CYP3A4
sofosbuvir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
succinylcholine BCHE
succinylcholine CACNA1S
No Dosing Guideline available DL CA VA No VIP available No VIP available
succinylcholine RYR1
sulfamethoxazole CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
sulfamethoxazole G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
sulfasalazine G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
sunitinib CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
tacrolimus CYP3A5
tamoxifen CYP2D6
tamoxifen ESR1
No Dosing Guideline available DL CA VA No VIP available No VIP available
tamoxifen ESR2
No Dosing Guideline available DL CA VA No VIP available No VIP available
tamoxifen F5
tegafur DPYD
telaprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
telithromycin CYP3A4
tetrabenazine CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
thioguanine TPMT
thioridazine CYP2D6
ticagrelor CYP2C19
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
ticagrelor CYP3A4
No Dosing Guideline available DL CA VA No VIP available No VIP available
ticagrelor CYP3A5
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
ticagrelor P2RY12
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
timolol CYP2D6
tolbutamide CYP2C9
tolterodine CYP2D6
tramadol CYP2D6
tramadol CYP3A4
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
trastuzumab ERBB2
trastuzumab emtansine ERBB2
trimethoprim G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
trimethoprim SLC22A2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
trimipramine CYP2C19
DG No Drug Label available CA VA No VIP available No VIP available
trimipramine CYP2D6
tropisetron CYP2D6
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
ustekinumab IL12B
No Dosing Guideline available DL CA VA No VIP available No VIP available
valproic acid CPS1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
valproic acid POLG
No Dosing Guideline available DL CA VA No VIP available No VIP available
vandetanib KDR
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
vemurafenib BRAF
vemurafenib NRAS
venlafaxine CYP2C19
venlafaxine CYP2D6
venlafaxine CYP3A4
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
voriconazole CYP2C19
voriconazole CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
voriconazole CYP3A4
No Dosing Guideline available DL CA VA No VIP available No VIP available
vortioxetine CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
warfarin CYP2C9
warfarin CYP4F2
warfarin PROC
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
warfarin PROS1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
warfarin VKORC1
zuclopenthixol CYP2D6