Selected PGx Associations

The criteria for this list of Drug-Gene pairs is 1) each pair must be annotated in either a dosing guideline annotation or a drug label annotation and 2) each pair must be specified in more than 1 type of annotation (dosing guideline, drug label, clinical annotation, variant annotation, VIP, or pathway).

Drug Gene Types of data
abacavir HLA-B
acenocoumarol CYP2C9
DG No Drug Label available CA VA No VIP available No VIP available
acetaminophen CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available PW
afatinib EGFR
allopurinol HLA-B
amitriptyline CYP2C19
anastrozole PGR
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
aripiprazole CYP2D6
atazanavir UGT1A1
atomoxetine CYP2D6
atorvastatin SLCO1B1
axitinib CYP2C19
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
azathioprine TPMT
belinostat UGT1A1
No Dosing Guideline available DL CA VA No VIP available No VIP available
boceprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
bosutinib ABL1
brivaracetam CYP2C19
No Dosing Guideline available DL CA VA No VIP available No VIP available
capecitabine DPYD
carbamazepine HLA-B
carisoprodol CYP2C19
carvedilol CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
celecoxib CYP2C9
cetuximab EGFR
chloroquine G6PD
cisplatin TPMT
No Dosing Guideline available DL CA VA No VIP available No VIP available
citalopram CYP2D6
clobazam CYP2C19
No Dosing Guideline available DL CA VA No VIP available No VIP available
clomipramine CYP2C19
clopidogrel CYP1A2
clozapine CYP2D6
codeine UGT2B7
dabrafenib BRAF
dapsone G6PD
dasatinib ABL1
daunorubicin SLC28A3
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
desflurane RYR1
desipramine CYP2D6
dextromethorphan CYP2D6
diazepam CYP2C19
dolutegravir UGT1A1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
doxepin CYP2D6
doxorubicin SLC28A3
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
duloxetine CYP2D6
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
efavirenz CYP3A4
erlotinib UGT1A1
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
escitalopram CYP2C19
esomeprazole CYP2C19
everolimus CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
exemestane ESR1
No Dosing Guideline available DL CA VA No VIP available No VIP available
fentanyl CYP3A4
fesoterodine CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
flecainide CYP2D6
fluorouracil DPYD
fluoxetine CYP2D6
flurbiprofen UGT2B7
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
fluvoxamine CYP2C19
galantamine CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
gefitinib CYP2D6
glibenclamide CYP2C9
gliclazide CYP2C9
DG No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
glimepiride CYP2C9
haloperidol CYP2D6
homoharringtonine ABL1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
hormonal contraceptives for systemic use F5
hydralazine NAT2
iloperidone CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
imatinib CYP3A4
imipramine CYP2C19
indacaterol ADRB2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
indinavir CYP3A4
irinotecan UGT1A1
isoflurane RYR1
isoniazid NAT2
ivacaftor CFTR
ivacaftor / lumacaftor CFTR
No Dosing Guideline available DL CA VA No VIP available No VIP available
lansoprazole CYP2C19
lapatinib ERBB2
letrozole CYP2A6
lidocaine CYP3A4
mafenide G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
mercaptopurine TPMT
methylene blue G6PD
metoclopramide CYB5R3
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
metoprolol CYP2D6
mirtazapine CYP2D6
DG No Drug Label available CA VA No VIP available No VIP available
moclobemide CYP2C19
modafinil CYP2C19
nalidixic acid G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
nelfinavir CYP3A4
nilotinib UGT1A1
No Dosing Guideline available DL CA VA No VIP available No VIP available
nitrofurantoin G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
nortriptyline CYP2D6
olanzapine CYP1A2
No Dosing Guideline available DL CA VA No VIP available No VIP available
omeprazole CYP2C19
oxcarbazepine CYP2C19
oxycodone CYP2D6
DG No Drug Label available CA VA No VIP available No VIP available
panitumumab KRAS
pantoprazole CYP2C19
paroxetine CYP2D6
pazopanib ABCG2
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
peginterferon alfa-2a IFNL3
DG No Drug Label available CA VA No VIP available No VIP available
peginterferon alfa-2b IFNL3
pegloticase G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
perphenazine CYP2D6
pertuzumab ERBB2
phenprocoumon CYP2C9
DG No Drug Label available CA VA No VIP available No VIP available
phenytoin CYP2C9
pimozide CYP3A4
ponatinib ABL1
prasugrel CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
pravastatin LDLR
No Dosing Guideline available DL CA VA No VIP available No VIP available
primaquine G6PD
probenecid G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
propafenone CYP2D6
propranolol CYP2C19
pyrazinamide NAT2
No Dosing Guideline available DL CA VA No VIP available No VIP available
quinidine ABCB1
quinine G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
rabeprazole CYP2C19
rasburicase G6PD
ribavirin IFNL3
DG No Drug Label available CA VA No VIP available No VIP available
rifampin NAT2
No Dosing Guideline available DL CA VA No VIP available No VIP available
risperidone CYP2D6
ritonavir CYP3A4
rosuvastatin CYP2C9
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
sertraline CYP2C19
DG No Drug Label available CA VA No VIP available No VIP available
sevoflurane RYR1
sildenafil CYP3A4
simeprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
simvastatin SLCO1B1
sirolimus CYP3A4
sofosbuvir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
succinylcholine RYR1
sulfamethoxazole G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
sulfasalazine G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
sunitinib CYP3A4
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
tacrolimus CYP3A5
tamoxifen CYP2D6
tegafur DPYD
telaprevir IFNL3
No Dosing Guideline available DL CA VA No VIP available No VIP available
telithromycin CYP3A4
tetrabenazine CYP2D6
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
thioguanine TPMT
thioridazine CYP2D6
ticagrelor CYP2C19
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
timolol CYP2D6
tolbutamide CYP2C9
tolterodine CYP2D6
tramadol CYP2D6
trastuzumab ERBB2
trastuzumab emtansine ERBB2
trimethoprim G6PD
No Dosing Guideline available DL CA VA No VIP available No VIP available
trimipramine CYP2C19
DG No Drug Label available CA VA No VIP available No VIP available
valproic acid CPS1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
vandetanib KDR
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available PW
vemurafenib BRAF
venlafaxine CYP2C19
vitamin c G6PD
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
voriconazole CYP3A4
No Dosing Guideline available DL CA VA No VIP available No VIP available
vortioxetine CYP2D6
No Dosing Guideline available DL CA VA No VIP available No VIP available
warfarin PROS1
No Dosing Guideline available DL No Clinical Annotation available VA No VIP available No VIP available
zuclopenthixol CYP2D6