Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study by Little K Y, McLaughlin D P, Zhang L, McFinton P R, Dalack G W, Cook E H, Cassin B J, Watson S J in Archives of general psychiatry (1998).

[PMID: 9736005] PubMed


Results of recent radioligand binding experiments suggest that chronic cocaine exposure increases dopamine transporter (DAT) synthesis throughout the striatum of humans. However, detection of cocaine binding site increases in animals and humans has varied depending on the radioligand used. The present experiment tested the hypothesis in cocaine-using humans that synthesis of midbrain DAT messenger RNA increases parallel with increased striatal DAT binding sites.

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