High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptives by Martinelli I, Sacchi E, Landi G, Taioli E, Duca F, Mannucci P M in The New England journal of medicine (1998).

[PMID: 9632445] PubMed


Idiopathic cerebral-vein thrombosis can cause serious neurologic disability. We evaluated risk factors for this disorder, including genetic risk factors (mutations in the genes encoding factor V and prothrombin) and nongenetic risk factors (such as the use of oral contraceptive agents). We compared the prevalence of these risk factors in 40 patients with cerebral-vein thrombosis, 80 patients with deep-vein thrombosis of the lower extremities, and 120 healthy controls. The G1691A mutation in the factor V gene and the G20210A prothrombin-gene mutation, which are established genetic risk factors for venous thrombosis, were studied. We also assessed the use of oral contraceptives and other risk factors for thrombosis.

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