Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174 by Kaukonen K M, Olkkola K T, Neuvonen P J in European journal of clinical pharmacology (1998).

[PMID: 9551703] PubMed


Losartan is metabolised to its active metabolite E-3174 by CYP2C9 and CYP3A4 in vitro. Itraconazole is an inhibitor of CYP3A4, whereas fluconazole affects CYP2C9 more than CYP3A4. We wanted to study the possible interaction of these antimycotics with losartan in healthy volunteers.

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