The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews by Struewing J P, Hartge P, Wacholder S, Baker S M, Berlin M, McAdams M, Timmerman M M, Brody L C, Tucker M A in The New England journal of medicine (1997).

[PMID: 9145676] PubMed


Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have an 85 percent risk of breast cancer. Since the combined frequency of BRCA1 and BRCA2 mutations exceeds 2 percent among Ashkenazi Jews, we were able to estimate the risk of cancer in a large group of Jewish men and women from the Washington, D.C., area.

[ hide abstract ]

Discussed In Paper


Rx Annotations

No dosing information annotated.