Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome by Monaghan G, Ryan M, Seddon R, Hume R, Burchell B in Lancet (1996).

[PMID: 8596320] PubMed


The genetic basis of Gilbert's syndrome is ill-defined. This common mild hyperbilirubinaemia sometimes presents as an intermittent jaundice. A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this syndrome. We have examined variation in the gene encoding the UGT1*1 enzyme and serum bilirubin levels in a Scottish population.

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