Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators by Feagan B G, Rochon J, Fedorak R N, Irvine E J, Wild G, Sutherland L, Steinhart A H, Greenberg G R, Gillies R, Hopkins M in The New England journal of medicine (1995). PubMed


Although corticosteroids are highly effective in improving symptoms of Crohn's disease, they may have substantial toxicity. In some patients, attempts to discontinue corticosteroids are unsuccessful.

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